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Smertesystemenes normale oppgaver er å beskytte og å gi instruks om hensiktsmessig atferd
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Smertesystemenes plastisitet gjør dem sårbare for feiltilpasninger som kan medføre spontan smerte og abnorm reaksjon på trivielle stimuli
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En del smertetilstander kan best forstås som hjernens tolking av kroppens tilstand på basis av ufullstendig og konfliktfylt informasjon
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