Melanoma, mole or sebaceous wart?

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    It can be difficult to distinguish between malignant melanoma, pigmented naevus and seborrheic keratosis. Curettage and punch biopsy are simple procedures that can be performed by a general practitioner to determine a diagnosis.

    Diagnosing malignant melanoma can be difficult. Seborrheic keratoses («sebaceous warts») and pigmented naevi (moles) are particularly easy to confuse with malignant melanoma.

    In the following we present, by means of text and video, three simple procedures that the general practitioner can perform in order to give patients a faster diagnosis and – in the case of malignant melanoma – earlier treatment and a better prognosis.

    Seborrheic keratoses

    Seborrheic keratoses

    Seborrheic keratoses are epidermal hyperkeratoses without malignant potential. These lesions are very common among the elderly, and are the most likely differential diagnosis when malignant melanoma is suspected in persons over the age of 40. Seborrheic keratoses develop over a period of weeks or months in middle aged persons. The lesions may vary in colour from light to dark brown (Fig. 1) and may loosen when handled or as a result of minor traumas. They leave small, temporary erosions, but may recur in the same place. Dermatoscopy shows a seborrheic keratosis to have a characteristic appearance with a verrucous surface and resembling a drop of wax (1). Such lesions are usually simple to diagnose with certainty.

    Figure 1  Photo montage of malignant melanoma, atypical pigmented naevus and seborrheic keratosis on the skin
    Figure 1 Photo montage of malignant melanoma, atypical pigmented naevus and seborrheic keratosis on the skin

    If there is still doubt about the diagnosis, however, the lesion should be removed by curettage (Video 1). The procedure is quick, easy to perform and requires no draping or suturing. If a keratotic material is easily removed and leaves a smooth, whitish, readily bleeding surface (Video 1), the diagnosis of seborrheic keratosis is confirmed. If any doubt persists, the curettage material should be sent for histological examination.

    Atypical pigmented naevi

    Atypical pigmented naevi

    Pigmented naevi with a diameter of > 5mm, irregular shape and varying colour are described in the dermatological literature as atypical or dysplastic pigmented naevi. They always have a macular (flat) component (2).

    Persons with five or more atypical pigmented naevi have a five to ten times higher risk of developing cutaneous malignant melanoma than persons without them (3). These lesions are an indicator of a skin type that is prone to developing malignant melanoma, rather than a precursor to melanoma in themselves (2).

    Dermatoscopy can be an aid in diagnosis, but requires both training and experience, which most GPs do not have (4). Because it may be difficult to distinguish an atypical pigmented naevus from a malignant melanoma, excisions should be performed in cases of doubt to obtain a definite diagnosis. Removal of small pigmented naevi, including atypical pigmented naevi, can be performed with the aid of a knife with a circular blade (Video 2). The lesion should be excised with a free margin. A histological examination will determine the diagnosis. If the lesion is larger than 6 mm, an ordinary, elliptical excision should be preferred (Video 3).

    Malignant melanoma

    Malignant melanoma

    Malignant melanoma is a serious form of cancer that develops from melanocytes, normally in skin.

    Early diagnosis and treatment with excision improves survival. The commonest and most important danger signals are growth and colour change, particularly the development of black areas. Special attention should be paid to pigmented lesions that differ from others in their appearance or development, often called the ugly duckling sign. The ABCDE rule (Box 1) is somewhat more complicated, and most relevant for health personnel (6, 7). The rule is based on the fact that most malignant melanomas are Asymmetrical, have an irregular Border, Colour variation with black parts, a Diameter of over 6 mm, and additionally that they have Evolving. The ABCDE rule is appropriate for identifying many cases of melanoma, but less so for nodular varieties: these have a symmetrical shape and also the poorest prognosis (8).

    BOX 1

    The ABCDE rule

    There are a number of signs that may distinguish a malignant melanoma from a benign pigmented naevus. These signs can be compiled into the ABCDE rule (7)

    • A:

      Asymmetry (two parts of the mole have different shapes)

    • B.

      Border (uneven border on the mole)

    • C:

      Colour (colour variation, often with black parts in the mole)

    • D:

      Diameter (mole is over 6 mm in diameter)

    • E:

      Evolving (the mole grows, or changes in some other way as described in the points above)

    If a doctor suspects, or cannot exclude the possibility of a diagnosis of malignant melanoma, the lesion should be excised in its entirety with at least 2 mm free margin, either with a punch (Video 2) or by means of an elliptical excision (Video 3). These are procedures that all GPs be competent in. If they are not, the patient must be referred with a clear and unambiguously formulated reference to a dermatologist or surgeon, who should see the patient within two weeks at the latest (9).

    Seborrheic keratoses versus malignant melanoma

    Seborrheic keratoses versus malignant melanoma

    Seborrheic keratoses may itch, grow rapidly and be dark coloured with black areas. They may therefore be difficult to distinguish from malignant melanoma on a clinical basis alone. The fact that a patient has several lesions with the same or almost the same appearance, is a strong indication of a diagnosis of seborrheic keratoses. Their greasy or verrucous consistency upon palpation distinguishes them from atypical pigmented naevi and malignant melanomas.

    Figure 2  Equipment necessary: curette, circular knife (punch) and scalpel
    Figure 2 Equipment necessary: curette, circular knife (punch) and scalpel

    Superficial spreading malignant melanoma is the most common type of melanoma. These lesions may be macular or only slightly elevated. The surface is smooth as a rule, not greasy and seldom verrucous. A nodular malignant melanoma usually has a smooth border, but may grow fast and still be less than 6 mm in diameter. The surface is seldom verrucous.

    Atypical pigmented naevi versus malignant melanoma

    Atypical pigmented naevi versus malignant melanoma

    Atypical pigmentus naevi do not normally itch, but itching is also a relatively rare symptom with malignant melanoma. Both atypical pigmentus naevi and malignant melanoma may have an irregular shape and colour. If the lesion has been stationary for several months without signs of change, this points to a diagnosis of atypical pigmentus naevi, since a malignant melanoma usually grows radially and/or changes its pigmentation over time. The development of new black areas irregularly distributed within the lesion is particularly characteristic of malignant melanoma.

    Table 1

    The most important differential diagnostic criteria for distinguishing malignant melanoma from seborrheic keratosis and atypical pigmented naevus

    Seborrheic keratosis

    Atypical pigmented naevus

    Malignant melanoma

    Patient's account of developments

    Age > 30 years

    Outgrowth

    Rapid growth

    Itching, irritation

    Often on trunk

    Age > 20 years

    Some similar lesions

    Little or no change

    No itching

    Often on trunk

    Age > 20 years

    Solitary, mole-like lesion that has changed in colour and shape

    Black component (90 %)

    Findings

    Several similar lesions

    Greasy

    Verrucous

    Homogenous

    May be black

    Bits loosen

    Pigmented lesion with irregular shape, colour and size

    Flat component

    Several with similar appearance

    Not greasy

    Solitary

    Pigmented lesion with black or heterogeneous colours that distinguish it from the others

    Not greasy consistence

    Differential diagnosis

    Melanoma:

    Not verrucous

    More heterogeneous in colour and shape

    Never several lesions of the same type

    Solar keratosis:

    Flat, dry, erythematous, seldom pigmented

    Melanoma:

    Greater irregularity in colour, black colour, solitary

    Seborrheic keratosis

    Pyogenic granuloma:

    Rapidly growing, bleeding tumour

    Atypical pigmented naevus:

    Little change, less colour variation

    Pigmented basalioma:

    often several small, similar lesions

    Diagnostic procedure

    Curettage, can be scraped off with slight bleeding

    Histological examination in case of doubt

    Punch excision if < 6 mm or ordinary boat-shaped total excision

    Histological examination

    Excision with 2 mm free margin

    Histological examination

    A malignant melanoma is normally larger than 5 mm in diameter. Patients can therefore be trained to recognise pigmented lesions that cannot be hidden behind the end of a pencil. This is called the pencil test. If such a lesion grows radially or changes shape/pigmentation, the suspicion of malignant melanoma is strengthened. We would then recommend either a clinical assessment and possibly excision, or a referral to a dermatologist/surgeon.

    Dermatoscopy performed by an experienced dermatoscopist will increase the chances of being able to distinguish an atypical pigmented naevus from malignant melanoma (10).

    Discussion

    Discussion

    In this article we have described the most important clinical symptoms and signs that distinguish seborrheic keratoses and atypical pigmented naevi from malignant melanomas. If there is still doubt about the diagnosis following the patient's account of developments and the clinical examination, we have presented three procedures (with video) which a general practitioner should be able to perform in order to ensure a definite diagnosis. We believe that increased use of these procedures can produce an earlier diagnosis and hence improve the prognosis in cases of malignant melanoma. At the same time, a more certain diagnosis of seborrheic keratoses and atypical pigmented naevi in general practice means a more rapid clarification for patients, and fewer referrals to the specialist health service.

    The persons in the film have given their consent to publication.

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