Main findings
Since the introduction of robot-assisted oesophageal and gastric resection for cancer at Oslo University Hospital, the incidence of anastomotic leakage, mortality rates and reoperation rates have been within national recommendations.
The method appears to be safe when performed at a centre with prior experience in minimally invasive surgery for oesophageal or gastric cancer.
In Norway, 673 new cases of oesophageal or gastric cancer were recorded in 2024 (1). Curative treatment involves perioperative chemo(radio)therapy combined with oesophageal or gastric resection (2). Both procedures are technically challenging, with morbidity rates of up to 60 % (3).
Over the past decade, there has been a marked increase in robot-assisted surgery in Norway and globally. Robot-assisted oesophageal resection has become a standard treatment at many centres internationally, and in 2024, 68 % of all oesophageal resections in Norway were performed wholly or partly using robot-assisted techniques (4, 5). During surgery for oesophageal or gastric cancer, lymph node dissection is routinely performed. Studies indicate that robot-assisted surgery is particularly effective for lymph node dissection compared with conventional minimally invasive surgery (6, 7).
The Norwegian Registry for Gastrointestinal Surgery (NORGAST) is a national quality register for surgical procedures involving organs of the digestive system. Individual hospitals report their own results to the registry. This allows each hospital to monitor its own outcomes with aggregated national data as a reference. Perioperative quality indicators are defined for the procedures included in the register, such as the incidence of anastomotic leakage, together with corresponding target levels and acceptable complication rates, which are determined by an expert advisory group (5). Despite the increasing use of robot-assisted surgery in Norway, few centres have reported their outcomes following the introduction of robot-assisted techniques. We therefore aim to present our experience with robot-assisted oesophageal and gastric resection, focusing on established quality indicators from NORGAST.
Material and method
We conducted a retrospective quality assurance study using prospectively registered data from patients undergoing robot-assisted oesophageal or gastric resection at Oslo University Hospital, Ullevål for oesophageal cancer and gastric cancer or precancerous lesions. Data were collected from three local prospective patient registers. Standard oncological treatment consisted of perioperative chemotherapy or neoadjuvant chemoradiotherapy followed by surgery.
All procedures were performed using the Da Vinci Xi surgical robot (Intuitive Surgical) by a team of four senior consultants, with at least two present for each operation. Robot-assisted gastric resection was introduced at Oslo University Hospital in November 2018, and robot-assisted oesophageal resection in November 2022.
We included patients in the study who underwent robot-assisted oesophageal resection for cancer between November 2022 and December 2024, or robot-assisted subtotal or total gastric resection for cancer or precancerous lesions between November 2018 and December 2024. Patients who were inoperable, who underwent alternative resections, or who were operated on using other surgical approaches were excluded.
We identified the proportion of patients with anastomotic leakage, 90-day mortality and reoperation, and examined the extent to which these rates fell within NORGAST's target levels (5). Reoperation is not included in NORGAST's quality indicators for patients undergoing oesophageal resection. Ninety-day mortality captures deaths that occur in the later postoperative period, for example following a prolonged stay in intensive care.
Surgical approach
Oesophagus. Surgery for oesophageal cancer requires access to both the thorax and the abdomen. All patients underwent oesophageal resection, lymph node dissection in the thorax and abdomen, and oesophagogastric anastomosis (Ivor Lewis oesophagectomy) (Figure 1). The robot was used in both the abdomen and thorax (2). The gastric conduit was anastomosed end-to-side, typically at or just above the carina using a circular stapler.
Abdomen. Patients underwent Roux-en-Y reconstruction with subtotal or total gastrectomy (Figure 2). In 91 patients, lymph node dissection was performed as recommended in the national gastric cancer guidelines (D2 dissection) (2). A linear stapler was used for the gastroenterostomy, and a circular or linear stapler for the oesophagojejunostomy (8).
Ethics
Patient data were recorded in a quality register approved by the data protection officer for the use of personal data for publication, as well as in consent-based quality and research registers.
Results
A total of 116 patients underwent oesophageal resection, 12 of whom were excluded due to gastrectomy with distal oesophageal resection (n = 2) or non-robot-assisted technique (n = 10). The remaining 104 patients were included. The median age was 65 years (range 30–82 years), 78 were men and 80 had received neoadjuvant oncological treatment. Histology included adenocarcinoma in 91 patients, squamous cell carcinoma in 11 and adenosquamous carcinoma in 2. Four procedures were converted to open surgery.
A total of 192 patients underwent surgery for gastric cancer or precancerous gastric lesions. Ninety-six patients were operated on laparoscopically. The remaining 96 patients were included in the study. The median age was 69 years (range 18–89 years), 54 were men and 48 had received neoadjuvant chemotherapy. Histology included adenocarcinoma in 84 patients and precancerous gastric lesions in 12. Two procedures were converted to open surgery.
Table 1 shows the quality indicators after robot-assisted oesophageal and gastric resection at Oslo University Hospital, compared with the national target levels specified in NORGAST. All quality indicators were within the target levels set by NORGAST.
Discussion
In this study of patients undergoing robot-assisted oesophageal and gastric resection at Oslo University Hospital, the incidence of anastomotic leakage, 90-day mortality and reoperation was within the national standards defined by the target levels set by NORGAST. Unlike the NORGAST annual report, this study presents exclusively the outcomes of patients operated on using a robot-assisted technique and represents the total institutional experience since robot-assisted procedures were established in 2018 (5). NORGAST's annual reports show that the proportion of robot-assisted procedures nationally for the oesophagus and abdomen, for both benign and malignant diseases, was 38.1 % and 17.4 % in 2022, and 67.7 % and 34.2 % in 2024, respectively (5, 9). Large-scale international multicentre studies report anastomotic leakage in approximately 20 % of robot-assisted oesophageal resections and 5 % of robot-assisted gastric resections (4, 10). The reoperation rate after gastric resection is reported to be around 7 % (10). Reported 90-day mortality is approximately 4 % for robot-assisted oesophageal resection and 5 % for robot-assisted gastric resection (11, 12). Our observations, which encompass the introduction of robot-assisted surgery, are therefore consistent with the outcomes reported by leading international centres.
Oslo University Hospital is one of four centres performing surgery for oesophageal or gastric cancer in Norway. During the study period, we performed approximately 60 oesophageal resections and 30 gastric resections annually. Prior to the introduction of robot-assisted surgery, operations were performed using minimally invasive techniques, specifically thoracolaparoscopic oesophageal resection from 2013 and laparoscopic gastric resection from 2015.
In April 2025, the Decision Forum (a governmental body responsible for approving new diagnostic and treatment methods in Norway) concluded that the evidence base for the use of robot-assisted surgery was limited. It was recommended that the acquisition of new surgical robots outside university hospitals be restricted to hospitals with sufficient volumes in rectal, prostate and uterine cancer surgery (13). We therefore believe it is particularly important to document outcomes using the technique, with special emphasis on validated quality indicators. We have previously published more detailed articles on the introduction of robot-assisted oesophageal and gastric resection at our department in international peer-reviewed journals (8, 14).
Throughout the study period, the department enlisted a large number of patients in a randomised trial (Kinetic) comparing the use of a nasogastric tube (standard treatment) with no tube (experimental treatment) after oesophageal resection (15). This was the only systematic change in postoperative patient management during the period and may have contributed to a higher incidence of anastomotic leakage than previously, as nasogastric tubes appear to protect against leakage, and there was an increased focus on leakage diagnostics during the study period (14).
The study suggests that robot-assisted oesophageal and gastric resection has been introduced safely at our institution, which has prior experience with minimally invasive surgery for oesophageal and gastric cancer.
The article has been peer-reviewed.
FHI. Kreft i spiserør og magesekk. Resultater for 2024. Rapport. https://www.fhi.no/contentassets/e48ffae32c644d87b9cb28e636e5ddb0/rapport-kreft-i-spiseror-og-magesekk-2024.pdf Accessed 17.12.2025.
Helsedirektoratet. Kreft i spiserør og magesekk – handlingsprogram Nasjonal faglig retningslinje 2024. https://www.helsedirektoratet.no/retningslinjer/kreft-i-spiseror-og-magesekk--handlingsprogram Accessed 5.10.2025.
van Nieuw Amerongen MP, de Grooth HJ, Veerman GL et al. Prediction of Morbidity and Mortality After Esophagectomy: A Systematic Review. Ann Surg Oncol 2024; 31: 3459–70. [PubMed][CrossRef]
Kooij CD, de Jongh C, Kingma BF et al. The Current State of Robot-Assisted Minimally Invasive Esophagectomy (RAMIE): Outcomes from the Upper GI International Robotic Association (UGIRA) Esophageal Registry. Ann Surg Oncol 2025; 32: 823–33. [PubMed][CrossRef]
Norsk register for gastrokirurgi. Årsrapport 2024. https://www.kvalitetsregistre.no/49da7b/siteassets/dokumenter/arsrapporter/gastrokirurgiregisteret/arsrapport-2024-norgast.pdf Accessed 8.10.2025.
Jia Z, Cao S, Wang D et al. Identification and Categorization of Technical Errors and Hazard Zones of Robotic Versus Laparoscopic Total Gastrectomy for Gastric Cancer: A Single-center Prospective Randomized Controlled Study. Ann Surg 2025; 282: 37–45. [PubMed][CrossRef]
Zhang Y, Dong D, Cao Y et al. Robotic Versus Conventional Minimally Invasive Esophagectomy for Esophageal Cancer: A Meta-analysis. Ann Surg 2023; 278: 39–50. [PubMed][CrossRef]
Mala T, Førland D, Skagemo C et al. Early experience with total robotic D2 gastrectomy in a low incidence region: surgical perspectives. BMC Surg 2022; 22: 137. [PubMed][CrossRef]
Norsk register for gastrokirurgi. Årsrapport 2022. https://kvalitetsregistre.fnsp.nhn.no/4a2ced/siteassets/dokumenter/arsrapporter/gastrokirurgiregisteret/arsrapport-2022-norgast_0.pdf Accessed 18.12.2025.
de Jongh C, Cianchi F, Kinoshita T et al. Surgical Techniques and Related Perioperative Outcomes After Robot-assisted Minimally Invasive Gastrectomy (RAMIG): Results From the Prospective Multicenter International Ugira Gastric Registry. Ann Surg 2024; 280: 98–107. [PubMed][CrossRef]
Perry R, Barbosa JP, Perry I et al. Short-term outcomes of robot-assisted versus conventional minimally invasive esophagectomy for esophageal cancer: a systematic review and meta-analysis of 18,187 patients. J Robot Surg 2024; 18: 125. [PubMed][CrossRef]
Takahashi C, Glasser J, Schuster C et al. Comparative outcomes of laparoscopic and robotic approaches to gastrectomy: a National Cancer Database study. Surg Endosc 2023; 37: 7530–7. [PubMed][CrossRef]
Nye metoder. Robotassistert kirurgi - Indikasjon VI. https://www.nyemetoder.no/metoder/robotassistert-kirurgi-indikasjon-vi/ Accessed 5.10.2025.
Hauge T, Johnson E, Fasting M et al. From conventional minimally invasive to robotic-assisted Ivor Lewis esophagectomy - A Nordic single-center retrospective study. Eur J Surg Oncol 2025; 51: 110417. [PubMed][CrossRef]
Hedberg J, Kauppila J, Aahlin EK et al. Nasogastric tube after oesophagectomy and risk of anastomotic leak: a Nordic, multicentre, open-label, randomised, controlled, non-inferiority trial. Lancet Reg Health Eur 2025; 57: 101411. [PubMed][CrossRef]